{"id":1667,"date":"2023-08-23T17:07:11","date_gmt":"2023-08-23T09:07:11","guid":{"rendered":"https:\/\/www.ucenbiomaterial.com\/?p=1667"},"modified":"2023-08-23T17:10:26","modified_gmt":"2023-08-23T09:10:26","slug":"1-2","status":"publish","type":"post","link":"https:\/\/www.ucenbiomaterial.com\/index.php\/2023\/08\/23\/1-2\/","title":{"rendered":"\u4e0a\u6d77\u6709\u673a\u6240\u7b49\u89e3\u6790\u9996\u4e2aPiezo\u590d\u5408\u7269\u4e09\u7ef4\u7ed3\u6784"},"content":{"rendered":"<h2 class=\"xl_title\" style=\"text-align: center;\">\u4e0a\u6d77\u6709\u673a\u6240\u7b49\u89e3\u6790\u9996\u4e2aPiezo\u590d\u5408\u7269\u4e09\u7ef4\u7ed3\u6784<\/h2>\n<div class=\"xl_title2\">\n<div class=\"fr_all\">\n<div id=\"_yybb_gen\" class=\"xfbb\"><\/div>\n<\/div>\n<\/div>\n<div class=\"xl_content\">\n<div class=\"view TRS_UEDITOR trs_paper_default trs_external 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\u3001\u4e0e\u5b54\u9053\u86cb\u767d\u6709\u76f4\u63a5\u548c\u7a33\u5b9a\u7684\u76f8\u4e92\u4f5c\u7528\u3001\u5728\u5f02\u6e90\u8868\u8fbe\u7cfb\u7edf\u4e2d\u80fd\u591f\u8c03\u63a7\u901a\u9053\u7279\u6027\u3001\u5728\u5185\u6e90\u7ec6\u80de\u4e2d\u80fd\u591f\u8c03\u63a7\u901a\u9053\u95e8\u63a7\u7279\u6027\u3002\u5c3d\u7ba1\u79d1\u5b66\u5bb6\u505a\u51fa\u4e86\u52aa\u529b\uff0c\u4f46\u76ee\u524d\u5c1a\u672a\u53d1\u73b0\u80fd\u591f\u6ee1\u8db3\u4ee5\u4e0a\u56db\u4e2a\u6807\u51c6\u7684Piezo\u9644\u5c5e\u4e9a\u57fa\uff0c\u963b\u788d\u4e86\u5bf9Piezo\u86cb\u767d\u4e0d\u540c\u95e8\u63a7\u7279\u6027\u5206\u5b50\u673a\u5236\u7684\u7814\u7a76\u3002<\/p>\n<p>8\u670818\u65e5\uff0c\u6fb3\u5927\u5229\u4e9aVictor Chang\u5fc3\u810f\u7814\u7a76\u6240Charles Cox\u8bfe\u9898\u7ec4\u4e0e\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u6709\u673a\u5316\u5b66\u7814\u7a76\u6240\u751f\u7269\u4e0e\u5316\u5b66\u4ea4\u53c9\u7814\u7a76\u4e2d\u5fc3\u5f20\u4e00\u5c0f\u8bfe\u9898\u7ec4\uff0c\u5728\u300a\u79d1\u5b66\u300b\uff08<em>Science<\/em>\uff09\u4e0a\uff0c\u53d1\u8868\u4e86\u9898\u4e3a\u300aMyoD\u5bb6\u65cf\u6291\u5236\u86cb\u767d\u4f5c\u4e3aPiezo\u901a\u9053\u7684\u8f85\u52a9\u4e9a\u57fa\u300b\uff08<em>MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels<\/em>\uff09\u7684\u7814\u7a76\u6587\u7ae0\u3002\u8be5\u7814\u7a76\u9996\u6b21\u62a5\u9053\u4e86MyoD\u5bb6\u65cf\u6291\u5236\u86cb\u767dMDFIC\u548cMDFI\u662fPiezo1\/2\u7684\u7ed3\u5408\u86cb\u767d\uff0c\u901a\u8fc7\u7ed3\u6784\u89e3\u6790\u548c\u529f\u80fd\u7814\u7a76\u53d1\u73b0MDFIC\u901a\u8fc7C\u672b\u7aef\u4e00\u6bb5\u9ad8\u5ea6\u8102\u8d28\u5316\u4fee\u9970\u7684\u4e24\u4eb2\u6027\u03b1\u87ba\u65cb\u4ece\u4fa7\u9762\u63d2\u5411Piezo\u7684\u5b54\u9053\u6a21\u5757\uff0c\u5e76\u8bc1\u5b9e\u8be5\u03b1\u87ba\u65cb\u80fd\u591f\u5f15\u8d77\u5916\u6e90\u548c\u5185\u6e90Piezo1\/2\u7684\u6162\u5931\u6d3b\u8fc7\u7a0b\u3002\u8be5\u7814\u7a76\u9274\u5b9a\u4e86\u9996\u4e2aPiezo\u86cb\u767d\u9644\u5c5e\u4e9a\u57fa\uff0c\u89e3\u91ca\u4e86\u5728\u8bb8\u591a\u7ec6\u80de\u7c7b\u578b\u4e2d\u89c2\u5bdf\u5230\u7684\u5185\u6e90Piezo\u901a\u9053\u622a\u7136\u4e0d\u540c\u7684\u95e8\u63a7\u7279\u6027\uff0c\u4e3aPiezo\u901a\u9053\u529f\u80fd\u673a\u5236\u7684\u7814\u7a76\u63d0\u4f9b\u4e86\u5168\u65b0\u65b9\u5411\u3002<\/p>\n<p>\u672c\u7814\u7a76\u5229\u7528CRISPR\/Cas9\u7f16\u8f91\u4eba\u771f\u76ae\u6210\u7ea4\u7ef4\u7ec6\u80de\u2002(hDF)\u2002\u4e2d\u7684Piezo1\uff08\u5728\u591a\u79cd\u7ec4\u7ec7\u6765\u6e90\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2dPiezo1\u8868\u73b0\u51fa\u8f83\u6162\u7684\u5931\u6d3b\u7279\u6027\uff09,\u2002\u901a\u8fc7\u4e09\u79cd\u4e0d\u540c\u7684\u7b56\u7565\u6765\u9274\u5b9aPiezo1\u7ed3\u5408\u86cb\u767d\u3002\u7814\u7a76\u7ecf\u8fc7\u4e25\u683c\u7684\u8d28\u8c31\u6570\u636e\u5206\u6790\uff0c\u786e\u5b9a\u4e09\u7ec4\u4e2d\u5747\u5b58\u5728\u4f46\u5728\u5404\u81ea\u7684\u9634\u6027\u5bf9\u7167\u4e2d\u4e0d\u5b58\u5728\u7684Piezo1\u76f8\u4e92\u4f5c\u7528\u86cb\u767d\u3002\u7814\u7a76\u4ec5\u9274\u5b9a\u51fa\u4e24\u79cd\u86cb\u767d\u8d28\u2014\u2014\u7b2c\u4e00\u79cd\u662fPiezo1\uff0c\u7b2c\u4e8c\u79cd\u662f\u7814\u7a76\u8f83\u5c11\u7684\u8f6c\u5f55\u8c03\u8282\u56e0\u5b50MDFIC\uff08\u56fe1\uff09\u3002\u7814\u7a76\u901a\u8fc7\u514d\u75ab\u5171\u6c89\u6dc0\u5728HEK293T\u7ec6\u80de\u4e2d\u9a8c\u8bc1\u4e86MDFIC\u4e0ePiezo1\/2\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n<p>\u4e3a\u63a2\u7a76MDFIC\u4e0ePiezo\u7684\u76f8\u4e92\u4f5c\u7528\u6a21\u5f0f\uff0c\u79d1\u7814\u4eba\u5458\u5229\u7528\u51b7\u51bb\u7535\u955c\u5355\u9897\u7c92\u4e09\u7ef4\u91cd\u6784\uff0c\u89e3\u6790\u4e86Piezo1-MDFIC\u590d\u5408\u7269\u7684\u9ad8\u5206\u8fa8\u7387\u4e09\u7ef4\u7ed3\u6784\uff0c\u53d1\u73b0\u4e86MDFIC\u901a\u8fc7C\u672b\u7aef\u4e00\u6bb5\u5bcc\u542b\u534a\u80f1\u6c28\u9178\u7684\u4e24\u4eb2\u6027\u03b1\u87ba\u65cb\u4ece\u4fa7\u9762\u63d2\u5411Piezo\u7684\u5b54\u9053\u6a21\u5757\u3002\u8be5\u03b1\u87ba\u65cb\u6a2a\u8eba\u4e8e\u78f7\u8102\u53cc\u5206\u5b50\u5c42\u5185\u4fa7\uff0c\u4e0ePiezo\u86cb\u767d\u7684\u591a\u4e2a\u6c28\u57fa\u9178\u5b58\u5728\u76f8\u4e92\u4f5c\u7528\u3002\u7814\u7a76\u663e\u793a\uff0c\u5728Piezo\u4e0eMDFIC\u4e0a\u5747\u6709\u80fd\u591f\u5f15\u8d77\u6dcb\u5df4\u7cfb\u7edf\u53d1\u80b2\u5f02\u5e38\u7684\u7a81\u53d8\u4f4d\u4e8e\u8be5\u76f8\u4e92\u4f5c\u7528\u754c\u9762\u4e0a\uff0c\u63d0\u793a\u4e86Piezo-MDIFC\u590d\u5408\u7269\u5728\u529f\u80fd\u4e0a\u7684\u91cd\u8981\u6027\uff08\u56fe2\uff09\u3002<\/p>\n<p>\u7531\u4e8eMDFIC\u7ed3\u5408\u5728Piezo\u7684\u5b54\u9053\u6a21\u5757\uff0c\u7814\u7a76\u63a8\u6d4bMDFIC\u53ef\u80fd\u4f1a\u8c03\u63a7Piezo\u7684\u95e8\u63a7\u7279\u6027\u3002\u901a\u8fc7\u5168\u7ec6\u80de\u819c\u7247\u94b3\uff0c\u7814\u7a76\u8bc1\u5b9eMDFIC\u548cMDFI\u80fd\u591f\u663e\u8457\u5f15\u8d77Piezo1\/2\u901a\u9053\u7684\u6162\u5931\u6d3b\u95e8\u63a7\u7279\u6027\u3002\u8be5\u95e8\u63a7\u7279\u6027\u662f\u7531\u4e0ePiezo\u76f8\u4e92\u4f5c\u7528\u7684\u6700C\u672b\u7aef\u7684\u4e24\u4eb2\u6027\u03b1\u87ba\u65cb\u6240\u4ecb\u5bfc\uff0c\u7f3a\u5931\u8be5\u03b1\u87ba\u65cb\u7684MDFIC\u5219\u4e0d\u80fd\u5f15\u8d77Piezo\u7684\u6162\u5931\u6d3b\u3002\u540c\u65f6\uff0c\u7814\u7a76\u9a8c\u8bc1\u4e86\u8be5\u03b1\u87ba\u65cb\u5bf9\u4e8e\u5185\u6e90Piezo\u7684\u6162\u5931\u6d3b\u540c\u6837\u91cd\u8981\uff08\u56fe3\uff09\u3002<\/p>\n<p>\u8fdb\u4e00\u6b65\uff0c\u7814\u7a76\u521d\u6b65\u63a2\u8ba8\u4e86MDIFC\u5f15\u8d77Piezo\u6162\u5931\u6d3b\u7684\u5206\u5b50\u673a\u5236\u3002\u7531\u4e8e\u5728Piezo1-MDFIC\u590d\u5408\u7269\u51b7\u51bb\u7535\u955c\u5bc6\u5ea6\u4e2d\uff0c\u4f4d\u4e8e\u7ec6\u80de\u819c\u4e00\u4fa7\u76845\u4e2a\u534a\u80f1\u6c28\u9178\u4e0a\u5747\u5177\u6709\u591a\u4f59\u7684\u5bc6\u5ea6\uff0c\u7814\u7a76\u63a8\u6d4b\u5176\u4e3a\u8102\u8d28\u5316\u4fee\u9970\u3002\u901a\u8fc7\u9170\u57fa\u751f\u7269\u7d20\u4ea4\u6362\u5b9e\u9a8c\uff0c\u7814\u7a76\u8bc1\u5b9eMDFIC\u7684C\u672b\u7aef\u5b58\u5728\u68d5\u6988\u9170\u5316\u4fee\u9970\u3002\u79d1\u7814\u4eba\u5458\u7814\u7a76\u4e86MDFIC\u8102\u8d28\u5316\u4fee\u9970\u5bf9Piezo\u95e8\u63a7\u7279\u6027\u7684\u5f71\u54cd\u3002\u7814\u7a76\u5c065\u4e2aCys\u7a81\u53d8\u4e3a5\u4e2aAla\u6216\u80055\u4e2aSer\u4e4b\u540e\uff0c\u7f3a\u5c11\u8102\u8d28\u5316\u4fee\u9970\u7684MDFIC\u4ecd\u80fd\u591f\u4e0ePiezo\u76f8\u7ed3\u5408\uff0c\u4f46\u65e0\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